In the first large-scale study of its kind, Dutch researchers demonstrated a strong linear relationship between decreased screening
performance and volumetric breast density. Involving more than 110,000 mammograms from the Dutch Breast Screening Program
the study showed that increasing volumetric breast density, as measured automatically by the Volpara Density software, impacts
mammography performance measures, such as sensitivity and the rates of recall, false positives, and interval cancers.